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Role of polygenic and environmental factors in the co-occurrence of depression and psychosis symptoms: a network analysis

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dc.contributor.author Liliana, Garcia-Mondragon untranslated
dc.contributor.author Konac, Deniz
dc.contributor.author Newbury, Joanne B.
dc.contributor.author Young, Katherine S.
dc.contributor.author Ing, Alex
dc.contributor.author Furtjes, Anna E.
dc.contributor.author Barker, Edward D.
dc.date.accessioned 2022-12-15T10:39:03Z
dc.date.available 2022-12-15T10:39:03Z
dc.date.issued 2022-06
dc.identifier.citation Garcia-Mondragon, L., Konac, D., Newbury, J.B. et al. Role of polygenic and environmental factors in the co-occurrence of depression and psychosis symptoms: a network analysis. Transl Psychiatry 12, 259 (2022). https://doi.org/10.1038/s41398-022-02022-9 tr_TR
dc.identifier.issn 2158-3188
dc.identifier.uri http://openacccess.atu.edu.tr:8080/xmlui/handle/123456789/4020
dc.identifier.uri https://doi.org/10.1038/s41398-022-02022-9
dc.description WOS indeksli yayınlar koleksiyonu. / WOS indexed publications collection. tr_TR
dc.description.abstract Depression and psychosis are often comorbid; they also have overlapping genetic and environmental risk factors, including trauma and area-level exposures. The present study aimed to advance understanding of this comorbidity via a network approach, by (1) identifying bridge nodes that connect clusters of lifetime depression and psychosis symptoms and (2) evaluating the influence of polygenic and environmental risk factors in these symptoms. This study included data from European ancestry participants in UK Biobank, a large population-based sample (N = 77,650). In Step 1, a network model identified bridge nodes between lifetime symptoms of depression and psychosis and functional impairment. In Step 2, genetic and environmental risk factors were incorporated to examine the degree to which symptoms associated with polygenic risk scores for depression and schizophrenia, lifetime exposure to trauma and area-level factors (including deprivation, air pollution and greenspace). Feelings of worthlessness, beliefs in unreal conspiracy against oneself, depression impairment and psychosis impairment emerged as bridges between depression and psychosis symptoms. Polygenic risk scores for depression and schizophrenia were predominantly linked with depression and psychosis impairment, respectively, rather than with specific symptoms. Cumulative trauma emerged as a bridge node associating deprivation with feelings of worthlessness and beliefs in unreal conspiracy, indicating that the experience of trauma is prominently linked with the co-occurrence of depression and psychosis symptoms related to negative views of oneself and others. These key symptoms and risk factors provide insights into the lifetime co-occurrence of depression and psychosis. tr_TR
dc.language.iso en tr_TR
dc.relation.ispartofseries 2022;Volume: 12 Issue: 1
dc.subject AIR-POLLUTION tr_TR
dc.subject DISORDERS tr_TR
dc.subject SCHIZOPHRENIA tr_TR
dc.subject RISK tr_TR
dc.subject EXPERIENCES tr_TR
dc.subject ASSOCIATION tr_TR
dc.subject DEPRIVATION tr_TR
dc.subject POPULATION tr_TR
dc.title Role of polygenic and environmental factors in the co-occurrence of depression and psychosis symptoms: a network analysis tr_TR
dc.type Article tr_TR

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