dc.contributor.author |
Babademez, Mehmet Ali |
|
dc.contributor.author |
Ozdas, Talih |
|
dc.contributor.author |
Ozdas, Sibel |
|
dc.date.accessioned |
2019-11-12T06:03:53Z |
|
dc.date.available |
2019-11-12T06:03:53Z |
|
dc.date.issued |
2016 |
|
dc.identifier.citation |
Babademez, M. A., Ozdas, T., & Ozdas, S. (2016). The common genetic variants of toll-like receptor and susceptibility to adenoid hypertrophy: A hospital-based cohort study. Turkish Journal of Medical Sciences, 46(5), 1449-1458. https://doi.org/10.3906/sag-1511-16 |
tr_TR |
dc.identifier.issn |
1300-0144 |
|
dc.identifier.issn |
1303-6165 |
|
dc.identifier.uri |
http://openaccess.adanabtu.edu.tr:8080/xmlui/handle/123456789/540 |
|
dc.identifier.uri |
https://doi.org/10.3906/sag-1511-16 |
|
dc.description |
WOS indeksli yayınlar koleksiyonu. / WOS indexed publications collection.
TR Dizin indeksli yayınlar koleksiyonu. / TR Dizin indexed publications collection. |
|
dc.description.abstract |
Background/aim: Adenoid hypertrophy (AH) is one of the most frequent pediatric disorders. The aim of this study was to investigate the effects of TLR2-R753Q, TLR4-T399I, and TLR4-D299G polymorphisms in children with AH.
Materials and methods: The variants of the TLR gene were determined by restriction fragment length polymorphism (PCR-RFLP) analysis in 60 patients with AH and in 50 healthy children. Data were analyzed with SNPStats and multifactor dimensionality reduction (MDR) software.
Results: We found that the presence of the G allele, the AG+GG and AG genotypes at TLR4-D299G, and the GGT haplotype were associated with AH in children (P = 0.013, P = 0.02, P = 0.038, and P = 0.001, respectively). On the contrary, no association was found between TLR2-R753Q and predisposition to AH. The CT genotype at TLR4-T399I showed a sex-specific association with AH, occurring only in boys with allergies (P = 0.0048). In addition, MDR analysis indicated a strong synergy between TLR gene markers contributing to AH. Allergic children with the diplotypes that included minor alleles of TLR4-D299G or TLR4-T399I had about a 4-fold increased risk for AH. |
tr_TR |
dc.language.iso |
en |
tr_TR |
dc.publisher |
TURKISH JOURNAL OF MEDICAL SCIENCES / TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY |
tr_TR |
dc.relation.ispartofseries |
2016;Volume: 46 Issue: 5 |
|
dc.subject |
Adenoid hypertrophy |
tr_TR |
dc.subject |
allergy |
|
dc.subject |
TLR2-R753Q |
|
dc.subject |
TLR4-D299G |
|
dc.subject |
TLR4-T399I |
|
dc.subject |
polymorphism |
|
dc.subject |
PCR-RFLP |
|
dc.subject |
TLR4 GENE |
|
dc.subject |
POLYMORPHISMS |
|
dc.subject |
CHILDREN |
|
dc.subject |
ASTHMA |
|
dc.subject |
ASSOCIATION |
|
dc.subject |
DISEASE |
|
dc.subject |
CD14 |
|
dc.subject |
ADENOTONSILLECTOMY |
|
dc.subject |
PHENOTYPES |
|
dc.subject |
RATIONALE |
|
dc.subject |
Medicine |
|
dc.subject |
General & Internal |
|
dc.subject |
Fen |
|
dc.subject |
Tıp |
|
dc.subject |
Cerrahi |
|
dc.title |
The common genetic variants of toll-like receptor and susceptibility to adenoid hypertrophy: a hospital-based cohort study |
tr_TR |
dc.type |
Article |
tr_TR |